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In addition to direct neuronal activation, MC-derived mediators further contribute to neuronal sensitization by increasing the activity of membrane-bound TRP channels, particularly TRPA1 and TRPV1, which lower the activation threshold of neurons and establish a state of peripheral hyperexcitability (40, 91, 103)

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Retrieved June 9, 2014.

Participants will attempt to quit smoking menthol cigarettes on a planned quit date, have 2 visits with research staff online or in-person at UAMS, and complete short daily surveys and 2 follow-up surveys that can be completed from your smartphone or in the comfort of your own home